Endocrine Abstracts

Introduction: Characteristically the discordant thyroid function test has been attributed to TSH-producing hypophyseal adenoma, familial dysalbuminemic hyperthyroxinemia and thyroid hormone resistance syndrome. We presented 2 cases with raised peripheral thyroid hormones with detectable TSH due to the presence of auto-antibodies against the peripheral thyroid hormones (PTAAb). <thead valign="...

Introduction: In patients with primary hyperaldosteronism, distinguishing between unilateral and bilateral adrenal hypersecretion is critical in assessing treatment options. Adrenal venous sampling (AVS) has been advocated by some to be the gold standard for localization of the responsible lesion however is invasive, technically challenging, and difficult to interpret. Adrenal computed tomographic scanning (TC) is mandatory before AVS but more studies are warranted to identify...

Introduction: Hypophysitis, an infrequent inflammatory condition of the pituitary gland, is typically managed with glucocorticoids, reserving surgery for significant mass effects and considering immunosuppressants or radiotherapy for refractory cases. Recent reports indicate positive outcomes with immunosuppressants. Here, we present a case of recurrent xanthogranulomatous hypophysitis in a 16-year-old female successfully treated with Rituximab.Case Repo...

Objectives: The effect of exposure to endocrine disruptors (exogenous chemical compounds that interfere with hormonal homeostasis), such as Bisphenol A (BPA) and Methyl Paraben (MPB), on gestational diabetes mellitus (GDM) has only been investigated in a small number of studies, with inconclusive results. Our objective was to investigate the association between concentrations of BPA and MPB in urine and the presence of DMG, insulin sensitivity and function of beta cells in a c...

Purpose: To evaluate the prevalence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) and its implications on cardiometabolic and surgical outcomes.Methods: A retrospective multicenter study of PA patients who underwent 1mg-dexamethasone suppression test (DST) in follow-up in 21 Spanish tertiary hospitals. ACS was defined as a cortisol post-DST >1.8μg/dL (confirmed ACS if >5μg/dL and possible ACS if between 1.8-...